{"id":32668,"date":"2025-02-13T11:47:50","date_gmt":"2025-02-13T11:47:50","guid":{"rendered":"https:\/\/www.seeachsod.org\/?post_type=articles&#038;p=32668"},"modified":"2025-02-13T11:48:45","modified_gmt":"2025-02-13T11:48:45","slug":"defining-down-syndrome","status":"publish","type":"articles","link":"https:\/\/www.seeachsod.org\/en\/articles\/defining-down-syndrome\/","title":{"rendered":"Defining Down Syndrome"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"32668\" class=\"elementor elementor-32668\" data-elementor-post-type=\"articles\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3a285f38 dir-ltr e-flex e-con-boxed e-con e-parent\" data-id=\"3a285f38\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-904a3d3 elementor-widget elementor-widget-eael-breadcrumbs\" data-id=\"904a3d3\" data-element_type=\"widget\" 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data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u201cBy Definition\u2026\u201d<\/strong><\/p><p>\u00a0<\/p><p><strong>By: Dr. M. Weil,<\/strong><\/p><p><strong>Chief physician at Seeach Sod,<\/strong><\/p><p><strong>Developmental pediatrician and pediatric specialist<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-acbb634 body-font mb-0 elementor-widget elementor-widget-text-editor\" data-id=\"acbb634\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Down Syndrome; Is genetic predisposition a factor in this syndrome?<\/strong><\/p><p>\u00a0<\/p><p>Down syndrome is the most common chromosomal disorder and is caused by the presence of an extra 21<sup>st<\/sup>\u00a0chromosome instead of the usual pair (hence it\u2019s other name \u201c<strong>trisomy 21\u201d). A person with Down syndrome has a total of 47 chromosomes in each cell instead of 46.<\/strong><\/p><p>\u00a0<\/p><p>In most cases (about 95%), there is full trisomy, meaning 3 complete 21<sup>st<\/sup>\u00a0chromosomes. Maternal age can impact the occurrence of trisomy 21, which is the result of irregular cell division. Women over the age of 35 are at a higher risk of giving birth to a Down syndrome child than their younger counterparts, although there are incidences of Down syndrome children born to young mothers. This condition is not hereditary and is unrelated to the parents\u2019 chromosomal chemistry.<\/p><p>\u00a0<\/p><p>Another form of Down syndrome is one which is called\u00a0<strong>mosaic Down syndrome<\/strong>. In such a condition, some of the cells in the body are normal while other cells have trisomy 21. Mosaic Down syndrome is manifested as a much milder form of the disorder and usually occurs as a result of irregular cell division and a partial correction of the abnormal division.<\/p><p>\u00a0<\/p><p>Heredity plays no role in both of these conditions and family members of individuals with Down syndrome are at no greater risk of giving birth to a child with Down syndrome.<\/p><p>\u00a0<\/p><p>In about 3-4% of individuals with Down syndrome, the disorder is due to a\u00a0<strong>chromosomal\u00a0<a title=\"Robertsonian translocation\" href=\"https:\/\/en.wikipedia.org\/wiki\/Robertsonian_translocation\">translocation<\/a><\/strong>\u00a0in one of the parents. In this case, chromosome 21 is attached to another chromosome, often\u00a0<a title=\"Chromosome 14 (human)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Chromosome_14_(human)\">chromosome 14<\/a>. A person with such a translocation has no signs of clinical Down syndrome and is completely normal (they don\u2019t have an extra chromosome; rather they have one less, 45, because one chromosome 21 is fused with another chromosome). However, carriers of chromosomal translocation have a greater chance of giving birth to a child with Down syndrome.<\/p><p>\u00a0<\/p><p>It is therefore important that individuals with Down syndrome and their parents undergo\u00a0<strong>chromosomal testing<\/strong>, in order to verify whether they are carriers of translocation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"article-category":[120],"class_list":["post-32668","articles","type-articles","status-publish","hentry","article-category-definitions"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Defining Down Syndrome - \u05e9\u05d9\u05d7 \u05e1\u05d5\u05d3 - \u05d3\u05e3 \u05d4\u05d1\u05d9\u05ea<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.seeachsod.org\/en\/articles\/defining-down-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Defining Down Syndrome - \u05e9\u05d9\u05d7 \u05e1\u05d5\u05d3 - \u05d3\u05e3 \u05d4\u05d1\u05d9\u05ea\" \/>\n<meta property=\"og:description\" content=\"\u05de\u05d0\u05de\u05e8\u05d9\u05dd Receive updates from Seeach Sod \u201cBy Definition\u2026\u201d \u00a0 By: Dr. M. Weil, Chief physician at Seeach Sod, Developmental pediatrician and pediatric specialist Down Syndrome; Is genetic predisposition a factor in this syndrome? \u00a0 Down syndrome is the most common chromosomal disorder and is caused by the presence of an extra 21st\u00a0chromosome instead of the [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.seeachsod.org\/en\/articles\/defining-down-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"\u05e9\u05d9\u05d7 \u05e1\u05d5\u05d3 - \u05d3\u05e3 \u05d4\u05d1\u05d9\u05ea\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-13T11:48:45+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.seeachsod.org\/en\/articles\/defining-down-syndrome\/\",\"url\":\"https:\/\/www.seeachsod.org\/en\/articles\/defining-down-syndrome\/\",\"name\":\"Defining Down Syndrome - \u05e9\u05d9\u05d7 \u05e1\u05d5\u05d3 - \u05d3\u05e3 \u05d4\u05d1\u05d9\u05ea\",\"isPartOf\":{\"@id\":\"https:\/\/www.seeachsod.org\/en\/#website\"},\"datePublished\":\"2025-02-13T11:47:50+00:00\",\"dateModified\":\"2025-02-13T11:48:45+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.seeachsod.org\/en\/articles\/defining-down-syndrome\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.seeachsod.org\/en\/articles\/defining-down-syndrome\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.seeachsod.org\/en\/articles\/defining-down-syndrome\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\",\"item\":\"https:\/\/www.seeachsod.org\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u05de\u05d0\u05de\u05e8\u05d9\u05dd\",\"item\":\"https:\/\/www.seeachsod.org\/en\/article_cat\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Definitions\",\"item\":\"https:\/\/www.seeachsod.org\/en\/article-category\/definitions\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Defining Down Syndrome\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.seeachsod.org\/en\/#website\",\"url\":\"https:\/\/www.seeachsod.org\/en\/\",\"name\":\"Seeachsod Wordpress\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.seeachsod.org\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.seeachsod.org\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.seeachsod.org\/en\/#organization\",\"name\":\"Seeachsod Wordpress\",\"url\":\"https:\/\/www.seeachsod.org\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.seeachsod.org\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.seeachsod.org\/wp-content\/uploads\/2024\/12\/cropped-logo_new.png\",\"contentUrl\":\"https:\/\/www.seeachsod.org\/wp-content\/uploads\/2024\/12\/cropped-logo_new.png\",\"width\":804,\"height\":418,\"caption\":\"Seeachsod Wordpress\"},\"image\":{\"@id\":\"https:\/\/www.seeachsod.org\/en\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Defining Down Syndrome - \u05e9\u05d9\u05d7 \u05e1\u05d5\u05d3 - \u05d3\u05e3 \u05d4\u05d1\u05d9\u05ea","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.seeachsod.org\/en\/articles\/defining-down-syndrome\/","og_locale":"en_US","og_type":"article","og_title":"Defining Down Syndrome - \u05e9\u05d9\u05d7 \u05e1\u05d5\u05d3 - \u05d3\u05e3 \u05d4\u05d1\u05d9\u05ea","og_description":"\u05de\u05d0\u05de\u05e8\u05d9\u05dd Receive updates from Seeach Sod \u201cBy Definition\u2026\u201d \u00a0 By: Dr. M. 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